DES1: A Key Driver of Lipotoxicity in Metabolic Disease
نویسندگان
چکیده
منابع مشابه
Vascular metabolic dysfunction and lipotoxicity.
The purpose of this study was to determine the role of lipotoxicity in vascular smooth muscle (VSM). C(1)-BODIPY 500/510 C(12) used to assess the ability of VSM A7r5 cells to transport long-chain fatty acids showed that lipid transport did not appear to limit metabolism. Thin layer chromatography revealed that storage of transported fatty acid occurred primarily as mono- and diglycerides and fa...
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Noncoding RNAs are an emerging class of nonpeptide regulators of metabolism. Metabolic diseases and the altered metabolic environment induce marked changes in levels of microRNAs and long noncoding RNAs. Furthermore, recent studies indicate that a growing number of microRNAs and long noncoding RNAs serve as critical mediators of adaptive and maladaptive responses through their effects on gene e...
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Visceral fat obesity plays an essential role in the clustering of atherosclerotic multiple risk factors in the metabolic syndrome. However, the mechanism by which visceral fat obesity causes clustering of glucose intolerance, high blood pressure, and dyslipidemia remains unknown. We have proposed a “lipotoxicity theory” as the mechanism behind metabolic syndrome and its consequences: an excess ...
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ژورنال
عنوان ژورنال: DNA and Cell Biology
سال: 2020
ISSN: 1044-5498,1557-7430
DOI: 10.1089/dna.2020.5402